Studies of neurological organoids, plant growth, and shifts in body fluids aboard the International Space Station as part of Expedition 71 are among the scientific investigations that NASA astronauts Matthew Dominick, Michael Barratt, Jeanette Epps, and Tracy C. Dyson will help support. The crew members are targeting launch to the space station in February and March.
Work scheduled for the space station during the upcoming expedition
Modeling neuroinflammation on the space station
Human Brain Organoid Models for Neurodegenerative Disease & Drug Discovery (HBOND) studies the mechanisms behind neuroinflammation, a common feature of neurodegenerative disorders. Researchers create organoids using patient-derived iPSCs (induced pluripotent stem cells) from patients with Parkinson’s disease and primary progressive multiple sclerosis.
The sixth space station organoid investigation, funded by the National Stem Cell Foundation, HBOND includes for the first time Alzheimer’s iPSCs and testing of the effects of drugs in development to treat neuroinflammation. Results could help improve diagnostics, provide insights into the effects of aging, accelerate drug discovery, and identify therapeutic targets for patients suffering from neurodegenerative diseases. The organoid models also could provide a way to anticipate how extended spaceflight affects the brain and support the development of countermeasures.
Protecting plants from spaceflight stressors
Plants can serve as a food source and provide other life-support services on long-term missions to the Moon and Mars. The Study on Plant Responses Against the Stresses of Microgravity and High Ultraviolet Radiation in Space (Plant UV-B) examines how stress from microgravity, UV radiation, and the combination of the two affect plants at the molecular, cellular, and whole organism levels. Results could increase understanding of plant growth in space and support improvements in plant cultivation technologies for future missions.
Reversing fluid shifts
Weightlessness causes fluids in the body to move toward the head, which can cause changes in eye structure and vision known as Spaceflight Associated Neuro-ocular Syndrome (SANS), along with other health problems. Mitigating Headward Fluid Shifts with Veno-constrictive Thigh Cuffs During Spaceflight (Thigh Cuff) examines whether thigh pressure cuffs could provide a simple way to counter this shift in body fluids and help protect astronauts from SANS and other issues on future missions to the Moon and Mars. Thigh cuffs could also help treat or prevent problems for patients on Earth with conditions that cause fluid accumulation in the head, such as long-term bed rest and diseases.
Incredible edible algae
Arthrospira-C (Art-C), an ESA (European Space Agency) investigation, analyzes how the cyanobacterium Limnospira responds to spaceflight conditions and whether it produces the same quantity and quality of oxygen and biomass in space as on Earth. These microalgae, also known as Spirulina, could be used to remove carbon dioxide exhaled by astronauts, which can become toxic in an enclosed spacecraft, and to produce oxygen and fresh food as part of life support systems on future missions.
Correct predictions of oxygen and biomass yields are crucial for the design of life support systems using bioprocesses. Spirulina has also been shown to have radioprotective properties, and eating it could help protect space travelers from cosmic radiation and conserve healthy tissue in patients undergoing radiation treatment on Earth.
